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Staphylococcus aureus Nuclease Is an SaeRS-Dependent Virulence Factor

5 Feb 2013

Abstract excerpt

Several prominent bacterial pathogens secrete nuclease (Nuc) enzymes that have an important role in combating the host immune response. Early studies of Staphylococcus aureus Nuc attributed its regulation to the agr quorum-sensing system. However, recent microarray data have indicated that nuc is under the control of the SaeRS two-component system, which is a major regulator of S. aureus virulence determinants....

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PMID: 23381999
DOI: 10.1128/iai.01242-12

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