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Article

Controlled Production of Stable Heterologous Proteins in <i>Lactococcus lactis</i>

1 Jun 2002

Abstract excerpt

The use of Lactococcus lactis (the most extensively characterized lactic acid bacterium) as a delivery organism for heterologous proteins is, in some cases, limited by low production levels and poor-quality products due to surface proteolysis. In this study, we combined in one L. lactis strain use of the nisin-inducible promoter P(nisA) and inactivation of the extracellular housekeeping protease HtrA. The ability...

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PMID: 12039780
DOI: 10.1128/aem.68.6.3141-3146.2002

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