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Article

Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.

The Journal of biological chemistry - 5 Feb 2010

Yuan Zengqiang, Kim Donghwa, Shu Shaokun, Wu Junbing, Guo Jianping, Xiao Lei, Kaneko Satoshi, Coppola Domenico, Cheng Jin Q

Abstract excerpt

The protein kinase mammalian sterile 20-like kinase 1 (MST1) is a mammalian homologue of the Drosophila hippo and plays a critical role in regulation of programmed cell death. MST1 exerts pro-apoptotic function through cleavage, autophosphorylation-Thr(183) and subsequent translocation to the nucleus where it phosphorylates a number of molecules, including LATS1/2, FOXO, JNK, and histone H2B. Here, we show that...

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Source

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Identifiers

PMID: 19940129
DOI: 10.1074/jbc.M109.059675
PMCID: PMC2823523

Genes

MST1
LATS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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