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Article

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.

The EMBO journal - 31 Oct 2007

Cinar Bekir, Fang Ping-Ke, Lutchman Mohini, Di Vizio Dolores, Adam Rosalyn M, Pavlova Natalya, Rubin Mark A, Yelick Pamela C, Freeman Michael R

Abstract excerpt

Akt kinases mediate cell growth and survival. Here, we report that a pro-apoptotic kinase, Mst1/STK4, is a physiological Akt1 interaction partner. Mst1 was identified as a component of an Akt1 multiprotein complex isolated from lipid raft-enriched fractions of LNCaP human prostate cancer cells. Endogenous Mst1, along with its paralog, Mst2, acted as inhibitors of endogenous Akt1. Surprisingly, mature Mst1 as well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17932490
DOI: 10.1038/sj.emboj.7601872
PMCID: PMC2063482

Genes

STK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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