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In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer

30 May 2018

Abstract excerpt

Osteopontin (OPN) has been shown to promote colorectal cancer (CRC) progression; however, the mechanism of OPN-induced CRC progression is largely unknown. In this study, we found that OPN overexpression led to enhanced anchorage-independent growth, cell migration and invasion in KRAS gene mutant cells but to a lesser extent in KRAS wild-type cells. OPN overexpression also induced PI3K signalling, expression of...

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PMID: 29851214
DOI: 10.1111/jcmm.13686

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