Article
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
Human molecular genetics - 1 Jan 2001
Randerson-Moor J A, Harland M, Williams S, Cuthbert-Heavens D, Sheridan E, Aveyard J, Sibley K, Whitaker L, Knowles M, Bishop J N, Bishop D T
Abstract excerpt
The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumours, commonly astrocytoma. Germline deletions of the region on 9p21 containing the CDKN2A and CDKN2B genes and CDKN2A exon 1beta have been reported in kindreds, implicating contiguous tumour suppressor gene deletion as a cause of this syndrome. We describe a family characterized by multiple melanoma and...
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