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Article

Association of circulating immune cell phenotypes and peripheral inflammatory biomarkers with depressive symptoms in the Framingham Heart Study.

Psychoneuroendocrinology - 1 Feb 2026

Iyer Sandhya, Cao Yumeng, Liebegott Ryan, Chen Jiachen, Ragab Ahmed, Doyle Margaret F, Lunetta Kathryn L, Murabito Joanne M

Abstract excerpt

BACKGROUND: Depression is a common mental health disorder with substantial impact on older adults. Immune dysfunction has been studied as a mechanism for depressive symptoms, providing the opportunity for new targeted treatment approaches. METHODS: This study investigated the associations between immune cell phenotypes, determined by flow cytometry, and peripheral inflammatory biomarkers, measured using the OLINK...

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Topics

Humans
Female
Male
Middle Aged
Depression
Biomarkers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Inflammation

Phenotype

Cohort Studies

Source

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Identifiers

PMID: 41349492
DOI: 10.1016/j.psyneuen.2025.107716
PMCID: PMC12801172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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