Article
A multigenic approach to evaluating prostate cancer risk in a systematic replication study.
Cancer genetics and cytogenetics - 1 Jun 2008
Hsu Fang-Chi, Lindström Sara, Sun Jielin, Wiklund Fredrik, Chen Shyh-Huei, Adami Hans-Olov, Turner Aubrey R, Liu Wennuan, Bälter Katarina, Kim Jin Woo, Stattin Pär, Chang Bao-Li, Isaacs William B, Xu Jianfeng, Grönberg Henrik, Zheng S Lilly
Abstract excerpt
Although it is well known that multiple genes may influence prostate cancer risk, most current efforts at identifying prostate cancer risk variants rely on single-gene approaches. In previous work using mostly single-gene approaches, we observed significant associations (P < 0.05) for 6 of 46 polymorphisms in five genes in a Swedish prostate cancer case-control study population. We now report on the higher-order...
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