Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis.

The Journal of biological chemistry - 25 Jul 2008

Steen Mårten, Tran Sinh, Autin Ludovic, Villoutreix Bruno O, Tholander Ann-Louise, Dahlbäck Björn

Abstract excerpt

Activated coagulation factor V functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin. Based on the introduction of extra carbohydrate side chains in recombinant factor V, we recently proposed several regions in factor Va to be important for factor Xa binding. To further define which residues are important for factor Xa binding, we prepared fifteen recombinant factor V variants in which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Chlorocebus aethiops

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COS Cells

Share to Factor Xa

Share to Mutagenesis, Site-Directed

Share to Prothrombin

Share to Thermodynamics

Share to Thromboplastin

Source

Open in PubMed Open full text

Identifiers

PMID: 18502757
DOI: 10.1074/jbc.M802703200
PMCID: PMC3258925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis.PMID 18502757Read ↗

Cleavage requirements for activation of factor V by factor Xa.Semantic proximity Read ↗

Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase.Semantic proximity Read ↗

Cooperative regulation of the activity of factor Xa within prothrombinase by discrete amino acid regions from factor Va heavy chain.Semantic proximity Read ↗

The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.Semantic proximity Read ↗

Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.Semantic proximity Read ↗

Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va.Semantic proximity Read ↗

Identification of the collagen-binding site of the von Willebrand factor A3-domain.Semantic proximity Read ↗

Amino acids Glu323, Tyr324, Glu330, and Val331 of factor Va heavy chain are essential for expression of cofactor activity.Semantic proximity Read ↗

Identification of a Putative Binding Site for Negatively Charged Surfaces in the Fibronectin Type II Domain of Human Factor XIISemantic proximity Read ↗

Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318.Semantic proximity Read ↗

Computational analysis of Asp519 and Glu665 mutations of coagulation factor FVIIIa: Implications for enhanced binding affinity of A2-domain.Semantic proximity Read ↗

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.