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Article

Cleavage requirements for activation of factor V by factor Xa.

European journal of biochemistry - 1 Jul 1997

Thorelli E, Kaufman R J, Dahlbäck B

Abstract excerpt

Coagulation factor V circulates in plasma as a single chain protein which expresses little procoagulant activity. After its activation by limited proteolysis by thrombin or factor Xa, factor Va functions as cofactor to factor Xa in the activation of prothrombin. Thrombin cleaves human factor V at Arg709, Arg1018 and Arg1545 and factor Va is formed by the heavy and light chains, which correspond to the N-terminal...

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Identifiers

PMID: 9249003
DOI: 10.1111/j.1432-1033.1997.00012.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cleavage requirements for activation of factor V by factor Xa.PMID 9249003Read ↗

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