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Article

Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.

The Journal of biological chemistry - 8 Aug 2008

Udagawa Tsuyoshi, Nemoto Naoki, Wilkinson Caroline R M, Narashimhan Jana, Jiang Li, Watt Stephen, Zook Aaron, Jones Nic, Wek Ronald C, Bähler Jürg, Asano Katsura

Abstract excerpt

int-6 is one of the frequent integration sites for mouse mammary tumor viruses. Although its product is the e-subunit of translation initiation factor eIF3, other evidence indicates that it interacts with proteasomes or other proteins to regulate protein stability. Here we report that the fission yeast int6(+) is required for overcoming stress imposed by histidine starvation, using the drug 3-aminotriazole (3AT)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18502752
DOI: 10.1074/jbc.M710017200
PMCID: PMC2494926

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast.PMID 18502752Read ↗

The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.Semantic proximity Read ↗

Genome-wide Screening of Regulators of Catalase Expression: ROLE OF A TRANSCRIPTION COMPLEX AND HISTONE AND tRNA MODIFICATION COMPLEXES ON ADAPTATION TO STRESS.Semantic proximity Read ↗

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.Semantic proximity Read ↗

Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.Semantic proximity Read ↗

Phosphorylation of the Transcription Factor Atf1 at Multiple Sites by the MAP Kinase Sty1 Controls Homologous Recombination and Transcription.Semantic proximity Read ↗

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The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1.Semantic proximity Read ↗

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The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expressionSemantic proximity Read ↗

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