Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis.

Journal of virology - 1 May 1991

Giachetti C, Semler B L

Abstract excerpt

A molecular genetic analysis has been combined with an in vitro biochemical approach to define the functional interactions required for nucleotidyl protein formation during poliovirus RNA synthesis. A site-directed lesion into the hydrophobic domain of a viral membrane protein produced a mutant virus that is defective in RNA synthesis at 39 degrees C. The phenotypic expression of this lesion affects initiation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to RNA, Viral
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 1850038
DOI: 10.1128/JVI.65.5.2647-2654.1991
PMCID: PMC240623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis.PMID 1850038Read ↗

A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.Semantic proximity Read ↗

Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket.Semantic proximity Read ↗

Enzymatic activity of poliovirus RNA polymerases with mutations at the tyrosine residue of the conserved YGDD motif: isolation and characterization of polioviruses containing RNA polymerases with FGDD and MGDD sequences.Semantic proximity Read ↗

Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation.Semantic proximity Read ↗

Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg.Semantic proximity Read ↗

Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.Semantic proximity Read ↗

Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses.Semantic proximity Read ↗

Mutational analysis of the role of nucleoside triphosphatase P4 in the assembly of the RNA polymerase complex of bacteriophage phi6.Semantic proximity Read ↗

Poliovirus RNA replication requires genome circularization through a protein-protein bridge.Semantic proximity Read ↗

Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA.Semantic proximity Read ↗

Functional and genetic plasticities of the poliovirus genome: quasi-infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants.Semantic proximity Read ↗

De novo synthesis of minus strand RNA by the rotavirus RNA polymerase in a cell-free system involves a novel mechanism of initiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.