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Article

Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis.

Journal of virology - 1 May 1991

Giachetti C, Semler B L

Abstract excerpt

A molecular genetic analysis has been combined with an in vitro biochemical approach to define the functional interactions required for nucleotidyl protein formation during poliovirus RNA synthesis. A site-directed lesion into the hydrophobic domain of a viral membrane protein produced a mutant virus that is defective in RNA synthesis at 39 degrees C. The phenotypic expression of this lesion affects initiation of...

Topics

Amino Acid Sequence
DNA, Viral
Gene Expression Regulation, Viral
Kinetics
Molecular Sequence Data
Mutation
Phenotype
Poliovirus
RNA, Viral
Temperature
Viral Envelope Proteins

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Identifiers

PMID: 1850038
DOI: 10.1128/JVI.65.5.2647-2654.1991
PMCID: PMC240623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1850038-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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