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Article

Poliovirus RNA replication requires genome circularization through a protein-protein bridge.

Molecular cell - 1 Mar 2001

Herold J, Andino R

Abstract excerpt

The mechanisms and factors involved in the replication of positive stranded RNA viruses are still unclear. Using poliovirus as a model, we show that a long-range interaction between ribonucleoprotein (RNP) complexes formed at the ends of the viral genome is necessary for RNA replication. Initiation of negative strand RNA synthesis requires a 3' poly(A) tail. Strikingly, it also requires a cloverleaf-like RNA...

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Identifiers

PMID: 11463383
DOI: 10.1016/s1097-2765(01)00205-2
PMCID: PMC7129834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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