Article
Comparison of DNA adduct levels associated with exogenous and endogenous exposures in human pancreas in relation to metabolic genotype.
Mutation research - 8 Mar 1999
Thompson P A, Seyedi F, Lang N P, MacLeod S L, Wogan G N, Anderson K E, Tang Y M, Coles B, Kadlubar F F
Abstract excerpt
Recently, we examined normal human pancreas tissue for DNA adducts derived from either exogenous chemical exposure and/or endogenous agents. In an effort to explain the different types and levels of DNA adducts formed in the context of individual susceptibility to cancer, we have focused on gene-environment interactions. Here, we report on the levels of hydrophobic aromatic amines (AAs), specifically those...
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