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Article

Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.

The Journal of biological chemistry - 18 Jul 2008

Mantuano Elisabetta, Mukandala Gatambwa, Li Xiaoqing, Campana W Marie, Gonias Steven L

Abstract excerpt

alpha(2)-Macroglobulin (alpha(2)M) is a plasma protease inhibitor, which reversibly binds growth factors and, in its activated form, binds to low density lipoprotein receptor-related protein (LRP-1), an endocytic receptor with cell signaling activity. Because distinct domains in alpha(2)M are responsible for its various functions, we hypothesized that the overall effects of alpha(2)M on cell physiology reflect...

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Identifiers

PMID: 18499670
DOI: 10.1074/jbc.M801762200
PMCID: PMC2459272

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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