Article
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion.
Neurobiology of disease - 1 Dec 2003
Hope Caroline, Mettenburg Joseph, Gonias Steven L, DeKosky Steven T, Kamboh M Ilyas, Chu Charleen T
Abstract excerpt
alpha(2)-Macroglobulin (alpha(2)M) is an abundant plasma/extracellular space protein implicated in clearance of amyloid beta (Abeta), a key constituent of Alzheimer's disease (AD) plaques. alpha(2)M also regulates proteinase and growth factor activities. In recent years, there have been >30 genetic studies debating the controversial role of a five-base-pair intronic deletion in the A2M gene in late-onset AD....
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