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Article

Activated α2-macroglobulin induces Müller glial cell migration by regulating MT1-MMP activity through LRP1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2013

Barcelona Pablo F, Jaldín-Fincati Javier R, Sánchez María C, Chiabrando Gustavo A

Abstract excerpt

In retinal proliferative diseases, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloprotease 2 (MMP-2) and MMP-9 also present increased levels of the protease inhibitor α2-macroglobulin (α2M) and its receptor, the low-density lipoprotein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23640058
DOI: 10.1096/fj.12-221598

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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