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Article

Sequence specificities of human fibroblast and neutrophil collagenases.

1 Apr 1991

Abstract excerpt

The sequence specificities of human fibroblast and neutrophil collagenases have been investigated by measuring the rate of hydrolysis of 60 synthetic oligopeptides covering the P4 through P'5 subsites of the substrate. The choice of peptides was patterned after both known cleavage sites in noncollagenous proteins and potential cleavage sites (those containing Gly-Ile-Ala, Gly-Leu-Ala, or Gly-Ile-Leu sequences)...

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PMID: 1849891
DOI: 10.1016/s0021-9258(20)89563-5

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