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Article

Unexpected crucial role of residue 272 in substrate specificity of fibroblast collagenase.

The Journal of biological chemistry - 26 Jul 2002

Tsukada Hiroki, Pourmotabbed Tayebeh

Abstract excerpt

Degradation of type I collagen by collagenases is an important part of extracellular remodeling. To understand the role of the hinge region of fibroblast collagenase in its collagenolytic activity, we individually substituted the 10 conserved amino acid residues at positions 264, 266, 268, 296, 272, 277, 284, 289, 307, and 313 in this region of the enzyme by their corresponding residues in MMP-3, a...

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PMID: 12011042
DOI: 10.1074/jbc.M201367200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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