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Article

Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase

1 Nov 1990

Abstract excerpt

A series of experiments has been carried out to characterize 58-kDa human neutrophil collagenase (HNC) and compare it with human fibroblast collagenase (HFC). N-Terminal sequencing of latent and spontaneously activated HNC shows that it is a distinct collagenase that is homologous to HFC and other members of the matrix metalloproteinase gene family. Activation occurs autolytically by hydrolysis of an M-L bond at...

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PMID: 2176876
DOI: 10.1021/bi00499a008

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