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Article

Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.

Cell death and differentiation - 1 May 2001

Byun Y, Chen F, Chang R, Trivedi M, Green K J, Cryns V L

Abstract excerpt

Caspases are key mediators of apoptosis. Using a novel expression cloning strategy we recently developed to identify cDNAs encoding caspase substrates, we isolated the intermediate filament protein vimentin as a caspase substrate. Vimentin is preferentially cleaved by multiple caspases at distinc...

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Identifiers

PMID: 11423904
DOI: 10.1038/sj.cdd.4400840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11423904-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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