Article
Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis.
Cell death and differentiation - 1 May 2001
Byun Y, Chen F, Chang R, Trivedi M, Green K J, Cryns V L
Abstract excerpt
Caspases are key mediators of apoptosis. Using a novel expression cloning strategy we recently developed to identify cDNAs encoding caspase substrates, we isolated the intermediate filament protein vimentin as a caspase substrate. Vimentin is preferentially cleaved by multiple caspases at distinct sites in vitro, including Asp85 by caspases-3 and -7 and Asp259 by caspase-6, to yield multiple proteolytic...
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