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Article

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

Cell death and differentiation - 1 Dec 2002

Jabbour A M, Ekert P G, Coulson E J, Knight M J, Ashley D M, Hawkins C J

Abstract excerpt

This study characterized the ability of a new member of the p35 family, p49, to inhibit a number of mammalian and insect caspases. p49 blocked apoptosis triggered by treatment with Fas ligand (FasL), Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or ultraviolet (UV) radiation but provided negligible protection against apoptosis induced by the chemotherapeutic drug cisplatin. The caspase cleavage...

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Identifiers

PMID: 12478468
DOI: 10.1038/sj.cdd.4401135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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