Article
BDNF-TrkB signaling and neuroprotection in schizophrenia.
Asian journal of psychiatry - 1 Feb 2013
Pandya Chirayu D, Kutiyanawalla Ammar, Pillai Anilkumar
Abstract excerpt
Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover,...
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