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Brd4 Regulation of Papillomavirus Protein E2 Stability

25 Jun 2009

Abstract excerpt

The papillomavirus (PV) E2 protein is an important regulator of the viral life cycle. It has diverse roles in viral transcription, DNA replication, and genome maintenance. Our laboratory has previously identified the cellular bromodomain protein Brd4 as a key interacting partner of E2. Brd4 mediates the transcriptional activation function of E2 and plays an important role in viral genome maintenance in dividing...

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PMID: 19553317
DOI: 10.1128/jvi.00674-09

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