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Article

Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy.

Journal of the American Chemical Society - 18 Jun 2008

Drew Simon C, Leong Su Ling, Pham Chi L L, Tew Deborah J, Masters Colin L, Miles Luke A, Cappai Roberto, Barnham Kevin J

Abstract excerpt

The interaction of the small (140 amino acid) protein, alpha-synuclein (alphaS), with Cu(2+) has been proposed to play a role in Parkinson's disease (PD). While some insight from truncated model complexes has been gained, the nature of the corresponding Cu(2+) binding modes in the full length protein remains comparatively less well characterized. This work examined the Cu(2+) binding of recombinant human alphaS...

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Identifiers

PMID: 18494470
DOI: 10.1021/ja800708x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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