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Article

Differences in the binding of copper(I) to α- and β-synuclein.

Inorganic chemistry - 5 Jan 2015

De Ricco Riccardo, Valensin Daniela, Dell'Acqua Simone, Casella Luigi, Gaggelli Elena, Valensin Gianni, Bubacco Luigi, Mangani Stefano

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the presence of abnormal α-synuclein (αS) deposits in the brain. Alterations in homeostasis and metal-induced oxidative stress may play a crucial role in the progression of αS amyloid assembly and pathogenesis of PD. Contrary to αS, β-synuclein (βS) is not involved in the PD etiology. However, it has been suggested that the βS/αS ratio is...

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Identifiers

PMID: 25495902
DOI: 10.1021/ic502407w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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