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Article

Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein.

Chemphyschem : a European journal of chemical physics and physical chemistry - 3 Dec 2021

Teng Xiangyu, Sheveleva Alena, Tuna Floriana, Willison Keith R, Ying Liming

Abstract excerpt

The interaction between α-synuclein (αSyn) and Cu2+ has been suggested to be closely linked to brain copper homeostasis. Disruption of copper levels could induce misfolding and aggregation of αSyn, and thus contribute to the progression of Parkinson's disease (PD). Understanding the molecular mechanism of αSyn-Cu2+ interaction is important and controversies in Cu2+ coordination geometry with αSyn still exists....

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Identifiers

PMID: 34617653
DOI: 10.1002/cphc.202100651
PMCID: PMC9293329

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Acetylation Rather than H50Q Mutation Impacts the Kinetics of Cu(II) Binding to α-Synuclein.PMID 34617653Read ↗

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