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Article

Analysis of siRNA specificity on targets with double-nucleotide mismatches.

Nucleic acids research - 1 May 2008

Dahlgren Cecilia, Zhang Hong-Yan, Du Quan, Grahn Maria, Norstedt Gunnar, Wahlestedt Claes, Liang Zicai

Abstract excerpt

Although RNA interference as a tool for gene knockdown is a great promise for future applications, the specificity of small interfering RNA (siRNA)-mediated gene silencing needs to be thoroughly investigated. Most research regarding siRNA specificity has involved analysis of affected off-target g...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18420656
DOI: 10.1093/nar/gkn190
PMCID: PMC2396434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18420656-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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