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Article

Analysis of siRNA specificity on targets with double-nucleotide mismatches.

Nucleic acids research - 1 May 2008

Dahlgren Cecilia, Zhang Hong-Yan, Du Quan, Grahn Maria, Norstedt Gunnar, Wahlestedt Claes, Liang Zicai

Abstract excerpt

Although RNA interference as a tool for gene knockdown is a great promise for future applications, the specificity of small interfering RNA (siRNA)-mediated gene silencing needs to be thoroughly investigated. Most research regarding siRNA specificity has involved analysis of affected off-target genes instead of exploring the specificity of the siRNA itself. In this study we have developed an efficient method for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18420656
DOI: 10.1093/nar/gkn190
PMCID: PMC2396434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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