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Article

Double-mismatched siRNAs enhance selective gene silencing of a mutant ALS-causing allele.

Acta pharmacologica Sinica - 1 Feb 2008

Geng Chang-ming, Ding Hong-liu

Abstract excerpt

AIM: Our previous study demonstrated an siRNA-mediated, allele-specific silencing of mutant genes that cause amyotrophic lateral sclerosis. To improve siRNA design for better therapeutic use of RNA interference, we systematically tested the base-pairing mismatch strategy in the design of asymmetric siRNA. METHODS: A naturally symmetric siRNA that targets the human Cu Zn superoxide dismutase G85R mutant allele was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

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Source

Identifiers

PMID: 18215350
DOI: 10.1111/j.1745-7254.2008.00740.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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