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Article

CD154 induces a switch in pro‐survival Bcl‐2 family members in chronic lymphocytic leukaemia

23 Aug 2007

Abstract excerpt

Chronic lymphocytic leukaemia cells survive and proliferate in patients but rapidly die in culture. The microenvironment that sustains leukaemic cells in vivo contains both stromal cell elements and T cells. We defined changes in Bcl-2 family protein expression on culture with CD40 ligand (CD154) expressed on mouse fibroblast L cells, and interleukin-4 (IL-4; CD154/IL-4 system): conditions that support survival...

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PMID: 17760804
DOI: 10.1111/j.1365-2141.2007.06717.x

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