Article
High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia.
International journal of cancer - 20 Feb 2005
Morales Alejo A, Olsson Anna, Celsing Fredrik, Osterborg Anders, Jondal Mikael, Osorio Lyda M
Abstract excerpt
In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and compared between 2 groups of B-CLL patients with either nonprogressive, indolent, previously...
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