Article
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
The Journal of biological chemistry - 25 Jul 2008
Wan Zhu-li, Huang Kun, Hu Shi-Quan, Whittaker Jonathan, Weiss Michael A
Abstract excerpt
The zinc insulin hexamer undergoes allosteric reorganization among three conformational states, designated T(6), T(3)R(3)(f), and R(6). Although the free monomer in solution (the active species) resembles the classical T-state, an R-like conformational change is proposed to occur upon receptor binding. Here, we distinguish between the conformational requirements of receptor binding and the crystallographic TR...
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