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Article

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993

Hua Q X, Shoelson S E, Inouye K, Weiss M A

Abstract excerpt

The solution structure of a diabetes-associated mutant human insulin (insulin Los Angeles; PheB24-->Ser) was determined by 13C-edited NMR spectroscopy and distance-geometry/simulated annealing calculations. Among vertebrate insulins PheB24 is invariant, and in crystal structures the aromatic ring appears to anchor the putative receptor-binding surface through long-range packing interactions in the hydrophobic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8421693
DOI: 10.1073/pnas.90.2.582
PMCID: PMC45707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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