Article
Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 1993
Hua Q X, Shoelson S E, Inouye K, Weiss M A
Abstract excerpt
The solution structure of a diabetes-associated mutant human insulin (insulin Los Angeles; PheB24-->Ser) was determined by 13C-edited NMR spectroscopy and distance-geometry/simulated annealing calculations. Among vertebrate insulins PheB24 is invariant, and in crystal structures the aromatic ring...
Topics
- Amino Acid Sequence
- Diabetes Mellitus, Type 2
- Humans
- Insulin
- Magnetic Resonance Spectroscopy
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Phenylalanine
- Protein Conformation
- Protein Structure, Secondary
- Receptor, Insulin
- Serine
- Structure-Activity Relationship