Article
Variants of CARD15, TNFA and PTPN22 and susceptibility to Crohn's disease in the Czech population: high frequency of the CARD15 1007fs.
Tissue antigens - 1 Jun 2008
Hradsky O, Lenicek M, Dusatkova P, Bronsky J, Nevoral J, Valtrova V, Kotalova R, Szitanyi P, Petro R, Starzykova V, Bortlik M, Vitek L, Lukas M, Cinek O
Abstract excerpt
Crohn's disease (CD) has been shown to be associated with the variants in the CARD15 gene as well as in other genes involved in the immune response. The frequencies of the variants profoundly differ among populations and so does the associated risk. We examined the associations of variants in the CARD15, TNFA and PTPN22 genes with pediatric-onset and adult-onset CD in the Czech population. Genotype, phenotype and...
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