Article
Expression in SPARC-null mice of collagen type I lacking the globular domain of the α1(I) N-propeptide results in abdominal hernias and loss of dermal collagen.
Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2010
Card Lauren, Henderson Nikki, Zhang Yuhua, Bornstein Paul, Bradshaw Amy D
Abstract excerpt
The sequence encoding the N-propeptide of collagen I is characterized by significant conservation of amino acids across species; however, the function of the N-propeptide remains poorly defined. Studies in vitro have suggested that one activity of this propeptide might be to act as a feedback inhibitor of collagen I synthesis. To determine whether the N-propeptide contributed to decreased collagen content in...
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