Article
Ectopic expression of SPARC in Xenopus embryos interferes with tissue morphogenesis: identification of a bioactive sequence in the C-terminal EF hand.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 May 1997
Damjanovski S, Karp X, Funk S, Sage E H, Ringuette M J
Abstract excerpt
SPARC is a matricellular Ca(2+)-binding glycoprotein that exhibits both counteradhesive and antiproliferative effects on cultured cells. It is secreted by cells of various tissues as a consequence of morphogenesis, response to injury, and cyclic renewal and/or repair. In an earlier study with Xen...
Topics
- Amino Acid Sequence
- Animals
- Blastomeres
- Mice
- Microinjections
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Osteonectin
- Peptides
- RNA, Messenger
- Rats
- Recombinant Proteins
- Xenopus