Article
Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens.
Molecular vision - 20 Jul 2004
Mansergh Fiona C, Wride Michael A, Walker Veronica E, Adams Steffan, Hunter Susan M, Evans Martin J
Abstract excerpt
PURPOSE: Sparc/osteonectin is a hydroxyapatite, calcium and, collagen binding protein, implicated in tissue morphogenesis, cell proliferation, and repair. Sparc null mice develop sub-cortical posterior cataract with eventual rupture of the lens. We wished to correlate genotype with phenotype in these mice via analysis of gene expression pattern changes leading to disease. METHODS: We carried out microarray...
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