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Article

Adverse life events and allele-specific methylation of the serotonin transporter gene (SLC6A4) in adolescents: the TRAILS study.

Psychosomatic medicine - 1 Apr 2015

van der Knaap Lisette J, Riese Harriëtte, Hudziak James J, Verbiest Michael M P J, Verhulst Frank C, Oldehinkel Albertine J, van Oort Floor V A

Abstract excerpt

OBJECTIVES: Adverse life events increase vulnerability to affective disorders later in life, possibly mediated by methylation of the serotonin transporter gene (SLC6A4). We investigated the relationship of SLC6A4 methylation with various types of adversity (perinatal adversity, traumatic youth experiences and stressful life events [SLEs]), as well as with the timing of SLEs (during childhood [0-11 years] or...

Topics

Adolescent
Alleles
Child
Child Abuse
DNA Methylation
Female
Humans
Life Change Events
Male
Netherlands
Prospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychological Trauma

Serotonin Plasma Membrane Transport Proteins

Stress, Psychological

Time Factors

Young Adult

Source

Identifiers

PMID: 25849128
DOI: 10.1097/PSY.0000000000000159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25849128-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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