The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.

doi:10.1128/JVI.72.9.7115-7124.1998

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Article

The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.

Journal of virology - 1 Sept 1998

Bates P A, DeLuca N A

Abstract excerpt

ICP4 of herpes simplex virus (HSV) is essential for productive infection due to its central role in the regulation of HSV transcription. This study identified a region of ICP4 that is not required for viral growth in culture or at the periphery of experimentally inoculated mice but is critical fo...

Topics

Amino Acid Sequence
Animals
Chlorocebus aethiops
DNA Replication
Gene Expression
Herpesvirus 1, Human
Humans
Immediate-Early Proteins
Mice
Molecular Sequence Data
Peptides
Phenotype
Trigeminal Ganglion
Vero Cells
Virus Latency

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