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Article

The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia.

Journal of virology - 1 Sept 1998

Bates P A, DeLuca N A

Abstract excerpt

ICP4 of herpes simplex virus (HSV) is essential for productive infection due to its central role in the regulation of HSV transcription. This study identified a region of ICP4 that is not required for viral growth in culture or at the periphery of experimentally inoculated mice but is critical for productive growth in the trigeminal ganglia. This region of ICP4 encompasses amino acids 184 to 198 and contains 13...

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Identifiers

PMID: 9696805
DOI: 10.1128/JVI.72.9.7115-7124.1998
PMCID: PMC109933

Genes

LAT

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Source receipt: pubmed, retrieved 7 Sept 2026.

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