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Article

Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice.

Journal of virology - 1 Dec 1992

Valyi-Nagy T, Deshmane S L, Raengsakulrach B, Nicosia M, Gesser R M, Wysocka M, Dillner A, Fraser N W

Abstract excerpt

Ocular infection of immunocompetent (BALB/c) mice with wild-type herpes simplex virus type 1 (HSV-1) 17+ may lead to acute fatal encephalitis; however, in surviving animals, a latent (nonproductive) infection of the nervous system is established. In contrast, 17+ infection invariably kills mice with severe combined immunodeficiency (SCID mice) within 2 weeks. Ocular infection of immunocompetent mice with a mutant...

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Identifiers

PMID: 1331523
DOI: 10.1128/JVI.66.12.7336-7345.1992
PMCID: PMC240438

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Source receipt: pubmed, retrieved 7 Sept 2026.

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