Article
Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice.
Journal of virology - 1 Dec 1992
Valyi-Nagy T, Deshmane S L, Raengsakulrach B, Nicosia M, Gesser R M, Wysocka M, Dillner A, Fraser N W
Abstract excerpt
Ocular infection of immunocompetent (BALB/c) mice with wild-type herpes simplex virus type 1 (HSV-1) 17+ may lead to acute fatal encephalitis; however, in surviving animals, a latent (nonproductive) infection of the nervous system is established. In contrast, 17+ infection invariably kills mice w...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Brain Stem
- Cell Line
- DNA, Viral
- Eye
- Female
- Gene Expression
- Herpes Simplex
- In Situ Hybridization
- Male
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Mutation
- Nervous System
- RNA, Viral