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Article

Mutational analysis of regulation of MHC and anti-viral genes.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1991

Rodgers J R, Wyde P R, Rich R R

Abstract excerpt

CTL-mediated selection for loss of expression of Mta by H-2-heterozygous SV40-transformed mouse fibroblasts (line 24SV) produced an unusual phenotypic class of maternally transmitted Ag negative mutants defective in both MHC expression and in anti-viral activity. Severely reduced surface expression of class I MHC Ag from multiple loci of both haplotypes correlated with low levels of MHC H chain and beta...

Topics

Animals
Cytotoxicity, Immunologic
Interferon-gamma
Kinetics
Major Histocompatibility Complex
Mice
Mutation
Phenotype
RNA, Messenger
T-Lymphocytes, Cytotoxic
Vesicular stomatitis Indiana virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viruses

Source

Identifiers

PMID: 1848575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1848575-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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