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Article

Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells.

Stem cells (Dayton, Ohio) - 1 Aug 2008

Santoni de Sio Francesca Romana, Gritti Angela, Cascio Paolo, Neri Margherita, Sampaolesi Maurilio, Galli Cesare, Luban Jeremy, Naldini Luigi

Abstract excerpt

The isolation of human embryonic and somatic stem cells of different types has made it possible to design novel gene and cell replacement therapies. Vectors derived from retro/lentiviruses are used to stably introduce genes into stem cells and their progeny. However, the permissivity to retroviral infection varies among cell types. We previously showed that hematopoietic stem cells are poorly permissive to human...

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Identifiers

PMID: 18483423
DOI: 10.1634/stemcells.2007-0705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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