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Article

Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.

Carcinogenesis - 1 May 2007

Zhang Bailin, Sun Tong, Xue Liyan, Han Xiaohong, Zhang Baoning, Lu Ning, Shi Yuankai, Tan Wen, Zhou Yifeng, Zhao Dan, Zhang Xuemei, Guo Yongli, Lin Dongxin

Abstract excerpt

The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system. This study examined the effects of FAS (-1377G/A and -670A/G) and FASL (-844T/C and 7896G/C) polymorphisms on breast cancer risk and apoptosis of T lymphocytes. The effect on breast cancer risk was determined by case-control analysis of 840 patients and 840 controls. The effects on T-lymphocyte apoptosis were determined...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17183065
DOI: 10.1093/carcin/bgl250

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.PMID 17183065Read ↗

Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases.Semantic proximity Read ↗

FAS-1377 A/G polymorphism in breast cancer: a meta-analysis.Semantic proximity Read ↗

Quantitative assessment of the association between three polymorphisms in FAS and FASL gene and breast cancer risk.Semantic proximity Read ↗

The diplotype Fas -1377A/-670G as a genetic marker to predict a lower risk of breast cancer in Chinese women.Semantic proximity Read ↗

Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.Semantic proximity Read ↗

Association of the polymorphisms in the Fas/FasL promoter regions with cancer susceptibility: a systematic review and meta-analysis of 52 studies.Semantic proximity Read ↗

Association between FAS 1377G>A polymorphism and breast cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Association between FAS gene -670 A/G and -1377 G/A polymorphisms and the risk of autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case-control studies.Semantic proximity Read ↗

FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer.Semantic proximity Read ↗

Association of Fas -1377 G/A polymorphism with susceptibility to cancer.Semantic proximity Read ↗

Evaluation of the Effect of Menopausal Status and BMI on Polymorphisms in Fas/Fas L and the Risk of Breast Cancer.Semantic proximity Read ↗

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