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Article

Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.

Cancer research - 15 May 2008

Ishii Hideshi, Mimori Koshi, Ishikawa Kazuhiro, Okumura Hiroshi, Pichiorri Flavia, Druck Teresa, Inoue Hiroshi, Vecchione Andrea, Saito Toshiyuki, Mori Masaki, Huebner Kay

Abstract excerpt

The fragile FHIT gene is among the first targets of DNA damage in preneoplastic lesions, and recent studies have shown that Fhit protein is involved in surveillance of genome integrity and checkpoint response after genotoxin exposure. We now find that Fhit-deficient hematopoietic cells, exposed to the genotoxin hydroquinone, are resistant to the suppression of stem cell in vitro colony formation observed with...

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Identifiers

PMID: 18483248
DOI: 10.1158/0008-5472.CAN-07-5687

Genes

FHIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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