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Article

Crystal Structure of the Dimerized N Terminus of Porcine Circovirus Type 2 Replicase Protein Reveals a Novel Antiviral Interface.

Journal of virology - 15 Sept 2018

Luo Gao, Zhu Xiongfei, Lv Yang, Lv Bomin, Fang Jin'e, Cao Shengbo, Chen Huanchun, Peng Guiqing, Song Yunfeng

Abstract excerpt

Two replicase (Rep) proteins, Rep and Rep', are encoded by porcine circovirus (PCV) ORF1; Rep is a full ORF1 transcript, and Rep' is a truncated transcript generated by splicing. These two proteins are crucial for the rolling-circle replication (RCR) of PCV. The N-terminal sequences of Rep and Rep' are identical and interact to form homo- or heterodimers. The three types of dimers perform different functions...

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Identifiers

PMID: 29976661
DOI: 10.1128/JVI.00724-18
PMCID: PMC6146719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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