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Article

Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease.

The Journal of biological chemistry - 5 Oct 1990

DiIanni C L, Davis L J, Holloway M K, Herber W K, Darke P L, Kohl N E, Dixon R A

Abstract excerpt

The pepsin-like aspartyl proteases consist of a single polypeptide chain with topologically similar amino- and carboxyl-terminal domains, each of which contributes 1 aspartic acid residue to the active site. This structure has been proposed to have evolved by gene duplication and fusion from a dimeric enzyme composed of two identical polypeptide chains, such as the aspartyl protease (PRT) of human...

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PMID: 2211628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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