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Article

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells

14 May 2008

Abstract excerpt

Telomerase is a ribonucleoprotein enzyme complex that adds telomeric repeats to the ends of chromosomes. The core telomerase components are the telomerase reverse transcriptase (TERT) catalytic subunit, and the telomerase RNA (TR) template subunit. In most cancers, telomerase is expressed at levels that are substantially higher than in normal cells. A known consequence of telomerase up-regulation which is...

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Identifiers

PMID: 18482052
DOI: 10.1111/j.1349-7006.2008.00815.x

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