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Article

Immunogenically optimized peptides derived from natural mutants of HIV CTL epitopes and peptide combinatorial libraries.

Biopolymers - 1 Jan 2008

Blondelle Sylvie E, Moya-Castro Rosa, Osawa Keiko, Schroder Kim, Wilson Darcy B

Abstract excerpt

Two strategies were aimed at identifying immunogenically optimized peptides for the potential use in the formulation of an effective prophylactic or therapeutic HIV-1 vaccine. Three CTL epitopes were investigated: Gag p24(19-27) TV9, Gag p17(77-85) SL9, and RT(309-317) IV9. The first strategy derives from the hypothesis that a number of rare mutant CTL epitopes of HIV-1 may be more immunogenic than the common...

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Share to Combinatorial Chemistry Techniques
Share to Cytotoxicity Tests, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Core Protein p24

Share to HLA-A2 Antigen

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Source

Identifiers

PMID: 18481808
DOI: 10.1002/bip.21020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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