Article
Identification of HIV vaccine candidate peptides by screening random phage epitope libraries.
Virology - 1 Apr 1993
Keller P M, Arnold B A, Shaw A R, Tolman R L, Van Middlesworth F, Bondy S, Rusiecki V K, Koenig S, Zolla-Pazner S, Conard P
Abstract excerpt
Most synthetic HIV-1 gp120 V3 loop peptides that are used as immunogens in experimental HIV-1 vaccine studies are modeled from the naturally occurring viral gp120 V3 loops. In experimental animals these immunogens generally elicit type (or variant)-specific neutralizing antibodies that are not broadly reactive among HIV-1 variants. In an attempt to find a more general structure for the V3 loop, we have obtained...
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