Minimal sequence requirements for synthetic peptides derived from the V3 loop of the human immunodeficiency virus type 1 (HIV-1) to enhance HIV-1 binding to cells and infection.

doi:10.1006/viro.1995.1003

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Article

Minimal sequence requirements for synthetic peptides derived from the V3 loop of the human immunodeficiency virus type 1 (HIV-1) to enhance HIV-1 binding to cells and infection.

Virology - 1 Feb 1995

Zanotto C, Calderazzo F, Dettin M, Di Bello C, Autiero M, Guardiola J, Chieco-Bianchi L, De Rossi A

Abstract excerpt

We previously demonstrated that a 23-mer peptide (DB3) derived from the V3 loop of the surface glycoprotein of HIV-1 MN strain was able to bind to soluble CD4 and enhance HIV-1 infection. The mechanism and structural features required for these biological activities were studied by using shortened DB3 derivatives and DB3 analogs carrying single amino acid substitutions. We found that peptides in which the...

Topics

Amino Acid Sequence
Antigens, CD
Binding Sites
CD4 Antigens
Cell Line
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Genetic Variation
HIV Core Protein p24

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Envelope Protein gp120

HIV-1

Humans

Models, Structural

Molecular Sequence Data

Peptides

Protein Conformation

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 7856094
DOI: 10.1006/viro.1995.1003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7856094-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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